Real-world Data from a Molecular Tumor Board Demonstrates Improved Outcomes with a Precision N-of-One Strategy
Next-generation sequencing (NGS) has allowed the identification of novel potential targets for patients with cancer. Examples of successful matching of tumor molecular alterations to cognate drugs include: NTRK inhibitors larotrectinib and entrectinib in multiple solid tumors with NTRK fusions1,2, ROS1 inhibitors entrectinib and crizotinib in non-small cell lung cancer (NSCLC) with ROS1 alterations3,4, and the FGFR inhibitor erdafitinib in FGFR-altered urothelial carcinoma5. Unfortunately, the majority of patients still do not benefit from single-agent targeted therapies, and most patients who do respond eventually develop resistance6,7,8….. Read More