Study shows that Metastatic cancers are “malignant snowflakes,” each having unique genomic portfolios
A study performed by UCSD oncologist and CureMatch co-founder Dr. Razelle Kurzrock and colleagues looked at 57 breast cancer patients using next-generation sequencing (NGS), and found that no two were the same. A total of 216 somatic aberrations were observed in 70 different genes, including 131 distinct aberrations.This supports a core principle of CureMatch’s approach, which looks at each cancer independently, based on its molecular tumor profile rather than the organ of origin of the tumor.
This study was published by UCSD oncologist and CureMatch co-founder Dr. Razelle Kurzrock and her colleagues in the journal Oncotarget. Co-authors on the article were JJ Wheler, BA Parker, JJ Lee, JT Atkins, F Janku, AM Tsimberidou, R Zinner, V Subbiah, S Fu, R Schwab, S Moulder, V Valero, M Schwaederle, R Yelensky, VA Miller, MP Stephens, F Meric-Bernstam, and Razelle Kurzrock.